Taubel, Jorge: search on Z-Library

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1

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single Rising TAK-438 (Vonoprazan) Doses in Healthy Male Japanese/non-Japanese Subjects

Sakurai, Yuuichi, Nishimura, Akira, Kennedy, Gale, Hibberd, Mark, Jenkins, Richard, Okamoto, Hiroyuki, Yoneyama, Tomoki, Jenkins, Helen, Ashida, Kiyoshi, Irie, Shin, Täubel, Jörg

Journal:

Clinical and Translational Gastroenterology

Year:

2015

Language:

english

File:

PDF, 657 KB

english, 2015

2

A Highly Durable RNAi Therapeutic Inhibitor of PCSK9

Fitzgerald, Kevin, White, Suellen, Borodovsky, Anna, Bettencourt, Brian R., Strahs, Andrew, Clausen, Valerie, Wijngaard, Peter, Horton, Jay D., Taubel, Jorg, Brooks, Ashley, Fernando, Chamikara, Kauff

Journal:

New England Journal of Medicine

Year:

2016

Language:

english

File:

PDF, 322 KB

english, 2016

3

The effects of steady-state erythromycin and azithromycin on the pharmacokinetics of sildenafil in healthy volunteers

Gary J. Muirhead, Stephen Faulkner, Jane A. Harness, Jörg Taubel

Journal:

British Journal of Clinical Pharmacology

Year:

2002

Language:

english

File:

PDF, 100 KB

english, 2002

4

Lamotrigine does not prolong QTc in a thorough QT/QTc study in healthy subjects

Ruth Dixon, Sarah Job, Ruth Oliver, Debra Tompson, John G. Wright, Kay Maltby, Ulrike Lorch, Jorg Taubel

Journal:

British Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 2.35 MB

english, 2008

5

Levofloxacin can be used effectively as a positive control in thorough QT/QTc studies in healthy volunteers

Jorg Taubel, Asif Naseem, Tomohiko Harada, Duolao Wang, Radivoj Arezina, Ulrike Lorch, A John Camm

Journal:

British Journal of Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 1.05 MB

english, 2010

6

Comparison of the effects of levofloxacin on QT/QTc interval assessed in both healthy Japanese and Caucasian subjects

Atsushi Sugiyama, Yuji Nakamura, Satomi Nishimura, Satomi Adachi-Akahane, Yuji Kumagai, Juleen Gayed, Asif Naseem, Georg Ferber, Jorg Taubel, John Camm

Journal:

British Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 784 KB

english, 2012

7

Mason-Likar electrode configuration can confound the recognition of electrode cable interchange

Velislav N. Batchvarov, Dilshat Djumanov, Jorg Taubel, A. John Camm

Journal:

Journal of Electrocardiology

Year:

2012

Language:

english

File:

PDF, 215 KB

english, 2012

8

Repeated supratherapeutic dosing of strontium ranelate over 15 days does not prolong QTc interval in healthy volunteers

Jorg Taubel, Asif Naseem, Duolao Wang, Radivoj Arezina, Ulrike Lorch, A. John Camm

Journal:

British Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 804 KB

english, 2012

9

Effects on 24-hour intragastric pH: a comparison of lansoprazole administered nasogastrically in apple juice and pantoprazole administered intravenously

James Freston, Yi-Lin Chiu, Wei-Jian Pan, Nancy Lukasik, Jörg Täubel

Journal:

American Journal of Gastroenterology

Year:

2001

Language:

english

File:

PDF, 1.09 MB

english, 2001

10

Insulin at normal physiological levels does not prolong QT c interval in thorough QT studies performed in healthy volunteers

Taubel, Jorg, Lorch, Ulrike, Ferber, Georg, Singh, Jatinder, Batchvarov, Velislav N., Savelieva, Irina, Camm, A. John

Journal:

British Journal of Clinical Pharmacology

Year:

2013

Language:

english

File:

PDF, 1.53 MB

english, 2013

11

Comparison of the Effects of Single and Repeated Oral Doses of Lansoprazole and Rabeprazole on Ambulatory 24-Hour Intragastric pH in Healthy Volunteers

Dr Keith G. Tolman, Jörg Täubel, Steven Warrington, Yi-Lin Chiu, Betsy L. Pilmer, Wei-Jian Pan

Journal:

Clinical Drug Investigation

Year:

2006

Language:

english

File:

PDF, 142 KB

english, 2006

12

NG lansoprazole or IV pantoprazole: Which provides better pH control?

Freston, James, Taubel, Jorg, Lukasik, Nancy, Pan, Wei-Jian, Chiu, Yi-Lin

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 166 KB

english, 2000

13

Lansoprazole achieves faster control of intragastric acidity than rabeprazole within the first 5 hours of administration

Tolman, Keith G., Taubel, Jorge, Warrington, Steven, Lukasik, Nancy, Pan, Wei-Jian, Chiu, Yi-Lin

Journal:

Gastroenterology

Year:

2000

Language:

english

File:

PDF, 183 KB

english, 2000

14

Three steps to writing adaptive study protocols in the early phase clinical development of new medicines

Ulrike Lorch,Martin O’Kane,Jorg Taubel

Journal:

BMC Medical Research Methodology

Year:

2014

Language:

english

File:

PDF, 897 KB

english, 2014

15

Analyzing the relationship of QT interval and exposure to Nitazoxanide , a prospective candidate for influenza antiviral therapy-A formal TQT study

Täubel, Jörg, Lorch, Ulrike, Rossignol, Jean-François, Ferber, Georg, John Camm, A.

Journal:

Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 673 KB

english, 2014

16

Shortening of the QT Interval After Food Can Be Used to Demonstrate Assay Sensitivity in Thorough QT Studies

Taubel, Jorg, Wong, Alex H., Naseem, Asif, Ferber, Georg, Camm, A. John

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 1.25 MB

english, 2012

17

Thorough QT study of the effect of oral moxifloxacin on QT c interval in the fed and fasted state in healthy Japanese and Caucasian subjects

Taubel, Jorg, Ferber, Georg, Lorch, Ulrike, Batchvarov, Velislav, Savelieva, Irina, Camm, A. John

Journal:

British Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 1.88 MB

english, 2014

18

Bupivacaine Extended Release Liposome Injection Does Not Prolong QTc Interval in a Thorough QT/QTc Study in Healthy Volunteers

Naseem, Asif, Harada, Tomohiko, Wang, Duolao, Arezina, Radivoj, Lorch, Ulrike, Onel, Erol, Camm, Alan John, Taubel, Jorg

Journal:

Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 604 KB

english, 2012

19

Effects on 24-hour intragastric pH: a comparison of lansoprazole administered nasogastrically in apple juice and pantoprazole administered intravenously

Freston, James, Chiu, Yi-Lin, Pan, Wei-Jian, Lukasik, Nancy, Taubel, Jorg

Journal:

American Journal of Gastroenterology

Year:

2001

Language:

english

File:

PDF, 1.09 MB

english, 2001

20

Tolerability and Pharmacokinetics of ACT-280778, a Novel Nondihydropyridine Dual L/T-type Calcium Channel Blocker

Mueller, Markus S., Shakeri-Nejad, Kasra, Gutierrez, Marcelo M., Krause, Andreas, Täubel, Jörg, Sanderson, Brian, Dingemanse, Jasper

Journal:

Journal of Cardiovascular Pharmacology

Year:

2014

Language:

english

File:

PDF, 579 KB

english, 2014

21

A Nonparametric Approach to QT Interval Correction for Heart Rate

Wang, Duolao, Cheung, Yin Bun, Arezina, Radivoj, Taubel, Jorg, Camm, Alan John

Journal:

Journal of Biopharmaceutical Statistics

Year:

2010

Language:

english

File:

PDF, 674 KB

english, 2010

22

Comparison of Six Commonly Used QT Correction Models and Their Parameter Estimation Methods

Wang, Duolao, Taubel, Jorg, Arezina, Radivoj

Journal:

Journal of Biopharmaceutical Statistics

Year:

2012

Language:

english

File:

PDF, 297 KB

english, 2012

23

The reproducibility of QTc changes after meal intake

Taubel, Jorg, Ferber, Georg

Journal:

Journal of Electrocardiology

Year:

2015

Language:

english

File:

PDF, 172 KB

english, 2015

24

Comparison of Digital 12-Lead ECG and Digital 12-Lead Holter ECG Recordings in Healthy Male Subjects: Results from a Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

Wang, Duolao, Bakhai, Ameet, Arezina, Radivoj, Täubel, Jörg

Journal:

Annals of Noninvasive Electrocardiology

Year:

2016

Language:

english

File:

PDF, 116 KB

english, 2016

25

Concentration-effect modeling based on change from baseline to assess the prolonging effect of drugs on QTc together with an estimate of the circadian time course

Ferber, Georg, Wang, Duolao, Täubel, Jörg

Journal:

Journal of Clinical Pharmacology

Year:

2014

Language:

english

File:

PDF, 175 KB

english, 2014

26

Stability of the Effect of a Standardized Meal on QTc

Täubel, Jörg, Fernandes, Sara, Ferber, Georg

Journal:

Annals of Noninvasive Electrocardiology

Year:

2016

Language:

english

File:

PDF, 345 KB

english, 2016

27

Thorough QT study of the effect of intravenous amisulpride on QTc interval in Caucasian and Japanese healthy subjects

Täubel, Jörg, Ferber, Georg, Fox, Gabriel, Fernandes, Sara, Lorch, Ulrike, Camm, A. John

Journal:

British Journal of Clinical Pharmacology

Year:

2016

Language:

english

File:

PDF, 717 KB

english, 2016

28

Estimation of the Power of the Food Effect on QTc to Show Assay Sensitivity

Ferber, Georg, Fernandes, Sara, Täubel, Jörg

Journal:

Journal of Clinical Pharmacology

Year:

2017

Language:

english

File:

PDF, 263 KB

english, 2017

29

Efficacy and Safety of MED2005, a Topical Glyceryl Trinitrate Formulation, in the Treatment of Erectile Dysfunction: A Randomized Crossover Study

Ralph, David J., Eardley, Ian, Taubel, Jorg, Terrill, Paul, Holland, Tim

Journal:

The Journal of Sexual Medicine

Year:

2018

Language:

english

File:

PDF, 376 KB

english, 2018

30

Confirmation of the Cardiac Safety of PGF 2α Receptor Antagonist OBE022 in a First-in-Human Study in Healthy Subjects, Using Intensive ECG Assessments

Täubel, Jörg, Lorch, Ulrike, Coates, Simon, Fernandes, Sara, Foley, Paul, Ferber, Georg, Gotteland, Jean-Pierre, Pohl, Oliver

Journal:

Clinical Pharmacology in Drug Development

Year:

2018

Language:

english

File:

PDF, 724 KB

english, 2018

31

Pharmacokinetics, safety and tolerability of OBE022, a selective prostaglandin F2α receptor antagonist tocolytic: A First-in-human trial in healthy post-menopausal women

Pohl, Oliver, Marchand, Line, Gotteland, Jean-Pierre, Coates, Simon, Täubel, Jörg, Lorch, Ulrike

Journal:

British Journal of Clinical Pharmacology

Year:

2018

Language:

english

File:

PDF, 874 KB

english, 2018

32

Single Doses up to 800 mg of E-52862 Do Not Prolong the QTc Interval – A Retrospective Validation by Pharmacokinetic-Pharmacodynamic Modelling of Electrocardiography Data Utilising the Effects of a Meal on QTc to Demonstrate ECG Assay Sensitivity

Täubel, Jörg, Ferber, Georg, Lorch, Ulrike, Wang, Duolao, Sust, Mariano, Camm, A. John, Ai, Tomohiko

Journal:

Year:

2015

Language:

english

File:

PDF, 2.11 MB

english, 2015

33

Pharmacokinetics, Safety and Cognitive Function Profile of Rupatadine 10, 20 and 40 mg in Healthy Japanese Subjects: A Randomised Placebo-Controlled Trial

Täubel, Jörg, Ferber, Georg, Fernandes, Sara, Lorch, Ulrike, Santamaría, Eva, Izquierdo, Iñaki, Liu, Zheng

Journal:

Year:

2016

Language:

english

File:

PDF, 1.84 MB

english, 2016

34

Pharmacokinetics and Pharmacodynamics of Lomitapide in Japanese Subjects

Taubel, Jorg, Sumeray, Mark, Lorch, Ulrike, McLean, Andre

Journal:

Journal of Atherosclerosis and Thrombosis

Year:

2016

Language:

english

File:

PDF, 732 KB

english, 2016

35

The Power of Phase I Studies to Detect Clinical Relevant QTc Prolongation: A Resampling Simulation Study

Ferber, Georg, Lorch, Ulrike, Täubel, Jörg

Journal:

BioMed Research International

Year:

2015

Language:

english

File:

PDF, 1.53 MB

english, 2015

36

Diurnal Profile of the QTc Interval Following Moxifloxacin Administration

Täubel, Jörg, Ferber, Georg, Fernandes, Sara, Camm, A. John

Journal:

Journal of Clinical Pharmacology

Year:

2018

Language:

english

File:

PDF, 931 KB

english, 2018

37

SP200A SUBCUTANEOUSLY ADMINISTERED INVESTIGATIONAL RNAI THERAPEUTIC (ALN-CC5) TARGETING COMPLEMENT C5 FOR TREATMENT OF PNH AND COMPLEMENT-MEDIATED DISEASES:INTERIM PHASE 1 STUDY RESULTS

Najafian, Nader, Hill, Anita, Taubel, Jorg, Bush, Jim, Borodovsky, Anna, Kawahata, Noriyuki, Mclean, Helen, Partisano, Angela, Chaturvedi, Prasoon, Sorensen, Benny

Journal:

Nephrology Dialysis Transplantation

Year:

2016

File:

PDF, 102 KB

2016

38

Efficient Design of Integrated and Adaptively Interlinked Protocols for Early-Phase Drug Development Programs

Coates, Simon, Pohl, Oliver, Gotteland, Jean-Pierre, Täubel, Jörg, Lorch, Ulrike

Journal:

Therapeutic Innovation & Regulatory Science

Year:

2019

File:

PDF, 670 KB

2019

39

The Cardiovascular Effects of a Meal: J-T peak and T peak -T end Assessment and Further Insights Into the Physiological Effects

Täubel, Jörg, Ferber, Georg, Van Langenhoven, Leen, del Bianco, Teresa, Fernandes, Sara, Djumanov, Dilshat, Kanters, Jørgen K., Graff, Claus, Camm, A. John

Journal:

Journal of Clinical Pharmacology

Year:

2019

Language:

english

File:

PDF, 580 KB

english, 2019

40

Efficient Design of Integrated and Adaptively Interlinked Protocols for Early-Phase Drug Development Programs

Coates, Simon, Pohl, Oliver, Gotteland, Jean-Pierre, Täubel, Jörg, Lorch, Ulrike

Journal:

Therapeutic Innovation & Regulatory Science

Year:

2019

Language:

english

File:

PDF, 670 KB

english, 2019

41

Practical risk management in early phase clinical trials

Coates, Simon, Täubel, Jörg, Lorch, Ulrike

Journal:

European Journal of Clinical Pharmacology

Year:

2019

Language:

english

File:

PDF, 705 KB

english, 2019

42

Co‐administration of the prostaglandin F2α receptor antagonist pre‐term labour drug candidate OBE022 with magnesium sulfate, atosiban, nifedipine and betamethasone

Pohl, Oliver, Marchand, Line, Gotteland, Jean‐Pierre, Coates, Simon, Täubel, Jörg, Lorch, Ulrike

Journal:

British Journal of Clinical Pharmacology

Year:

2019

File:

PDF, 620 KB

2019

43

HEMODYNAMIC EFFECTS OF NITROXYL DONOR BMS-986231 COMPARED TO NITROGLYCERIN OR PLACEBO IN PATIENTS WITH CHRONIC HEART FAILURE-A RANDOMIZED DOUBLE-BLIND CROSSOVER TRIAL

Felker, G. Michael, McMurray, John, Cleland, John, O'Connor, Christopher, Teerlink, John, Voors, Adriaan, Lang, Ninian, Ahmad, Faheem, Taubel, Jorg, Koehorst-Hodes, Anke, Newby, David E., Karra, Ravi,

Journal:

Journal of the American College of Cardiology

Year:

2020

File:

PDF, 195 KB

2020

44

ETHNIC SENSITIVITY STUDY OF THE EXTRA-FINE SINGLE-INHALER TRIPLE THERAPY BECLOMETHASONE DIPROPIONATE/FORMOTEROL FUMARATE/GLYCOPYRRONIUM BROMIDE (BDP/FF/GB) PRESSURISED METERED DOSE INHALER (PMDI) IN HEALTHY JAPANESE AND CAUCASIAN SUBJECTS

Delestre-Levai, Irisz, Taubel, Jorg, Tulard, Anne, Vele, Andrea, Cella, Massimo, Georges, George

Journal:

Year:

2020

File:

PDF, 64 KB

2020

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